Serrapeptase supplement side effects, benefits, research studies, dosage and use as proteolytic enzyme Information
Serrapeptase or Serratiopeptidase, an enzyme
isolated from a microorganism in silkworm, is widely used in clinical practice
in Japan. Until more is known about the long term benefit and side effects of
serrapeptase supplements, we recommend limiting daily dose to 20,000 units and
taking breaks from use.
Enteric Coated - pH Resistant
Developed by Dr. Ray Sahelian, M.D.
Manufactured by a FDA approved and GMP certified facility.
The silkworm has serrapeptase (also known as Serratio Peptidase or serratiopeptidase), a proteolytic enzyme. This enteric coated serrapeptase product is of the highest quality available. It is manufactured by a FDA approved facility. You can be sure you are getting exactly what you pay for.
Serrapeptase or serratiopeptidase, isolated from the microorganism Serratia E15,
naturally present in the silkworm intestine which allows the emerging moth to
dissolve its cocoon. Clinical use of serrapeptase in Europe and Asia spans over
twenty five years.
Serrapeptase - 200mg *
SerratioPeptidase (20,000 units enteric coated granules - 120,000 units per gram)
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Suggested use: The label says one or two
serrapeptase once or twice a day, but we suggest you limit your use to one serrapeptase
tablet daily until more research is available. Do not exceed 5 tablets a
week until more research is published with serrapeptase. We don't suggest using
40,000 units since the benefits and risks on this high dose are not clearly
understood. Discuss with your doctor
regarding the use of serrapeptase before self-medicating.
* Serratiopeptidase daily value not established.
Serrapeptase appears to be a supplement with some clinical potential, however much more research is needed before we determine what clinical role this enzyme has in medicine. In the meantime, only use serrapeptase under medical supervision until more studies determine the full spectrum of serrapeptase side effects and benefits.
Conditions where serrapeptase has been studied
Chronic airway lung disease
Chronic ear, nose or throat disorders
Carpal tunnel syndrome
Serrapeptase has even been studied in certain cases of edema after an operation or injury.
Q. My wife has conditions that she feels a
serrapeptase product would help in her treatment of these conditions. First of
all, she would like to know how long it takes for serrapeptase to start working
in her system. She would also like to know how long she will need to take it,
will it be something she will need to take temporarily or will it be long term,
or would that depend on the condition she is taking it for. She has fibromyalgia,
osteoporosis, rheumatoid arthritis, sjogrens syndrome, and was born with spastic
cerebral palsy. Any clinical information regarding treatment of these conditions
with serrapeptase would also be appreciated.
A. Due to limited human research with this proteolytic enzyme, it is difficult to predict its effects on the various conditions you mention. We suggest her doctor review the research on this product and suggest whether it is worth trying.
effects - caution
A review of the medical literature indicates rare cases of pneumonitis or allergic skin reactions with the use of serrapeptase. As with any supplement or medicine, rare cases of other side effects are possible. Over the past 3 years we have had four individuals who have mentioned side effects, and these were minor aches and pains after taking serrapeptase daily for a few weeks. For this reason, we suggest limiting to one serrapeptase tablet a day and taking at least 2 days off each week until we find out whether these cases were just coincidence or true side effects from serrapeptase.
Serrapeptase for chronic lung
disease and mucus
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
Respirology. 2003 Sep;8(3):316-20.
The proteolytic enzyme serrapeptase is widely used in clinical practice in Japan. We investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. This study was an open-labeled trial with a non-treatment control group. Patients were randomly assigned to oral treatment and without serrapeptase 30 mg/day for 4 weeks. Patients collected sputum samples for about 4 hours in the morning on the day the trial began and 4 weeks later. Part of each sputum sample was weighed and then completely dried and reweighed. The percentage solid component, viscosity and elasticity of the sputum were measured. Mucociliary transportability index was measured using ciliated bovine trachea ex vivo. After 4 weeks of serrapeptase treatment, sputum weight in the morning, percentage solid component, viscosity and elasticity of sputum, sputum neutrophil count, frequency of coughing and frequency of expectoration significantly decreased. Serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.
Serratiopeptidase research update
The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection.
J Bone Joint Surg Am. 2006 June. Animal Research Laboratory, Marmara University School of Medicine, Istanbul, Turkey.
Infection around an implanted orthopedic device is a devastating complication, and the treatment of infections involving slime-forming bacteria is especially difficult. The purpose of the present study was to evaluate the effectiveness of a proteolytic enzyme, serratiopeptidase, in the eradication of a periprosthetic infection in an in vivo animal model. In sixty Sprague-Dawley rats, the medullary canal of the right femur was drilled through the intercondylar notch and was inoculated with a Staphylococcus epidermidis strain with a high slime-producing capacity. The cavity was filled with polymethylmethacrylate cement, and a Kirschner wire that had contact with the knee joint was inserted. None of the animals received any treatment for two weeks. One group received serratiopeptidase enzyme injections into the knee joint in addition to antibiotic therapy for four weeks, and the other group received intra-articular saline solution injections together with the same antibiotic therapy. Serratiopeptidase was effective for eradicating infection caused by biofilm-forming bacteria in this experimental animal model. The antibiofilm property of the enzyme may enhance antibiotic efficacy in the treatment of staphylococcal infections.
A preliminary trial of serratiopeptidase in patients with carpal tunnel
J Assoc Physicians India. 1999 Dec;47(12):1170-2.
This study was planned to assess the response of serratiopeptidase ( serrapeptase ) in patients with carpal tunnel syndrome. Twenty patients with carpal tunnel syndrome were evaluated clinically. After baseline electrophysiological studies, these patients were given serrapeptase 10 mg twice daily with initial short course of nimesulide. Clinical and electrophysiological reassessment was done after 6 weeks. Sixty five percent of serrapeptase cases showed significant clinical improvement which was supported by improvement in electrophysiological parameters. Recurrence was reported in four cases. No significant side effect was observed. Serrapeptase therapy may proved to be a useful alternative mode of conservative treatment. Larger study may be further helpful to establish the role of serrapeptase in carpal tunnel syndrome. Serratiopeptidase therapy.
Intestinal absorption of serrapeptase in rats.
Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1):101-8.
A sensitive sandwich enzyme immunoassay for serrapeptase, an orally available anti-inflammatory proteinase, was established. Serrapeptase in the plasma was determined after its oral administration (100 mg/kg) to rats. The peak concentration was observed between 30 min and 2 h after administration. These results indicate that orally administered serrapeptase was absorbed from the intestinal tract and transferred into the circulation in an enzymically active form.
Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.
University of Naples, Italy.
J Int Med Res. 1990 Sep-Oct;18(5):379-88.
The efficacy and tolerability of serrapeptase were evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. Treatment lasted 7-8 days, with the drug or placebo being administered at a rate of two tablets three times a day. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. There was also a significant reduction in symptoms after 7-8 days for patients in both treatment groups but the response was more marked in those patients receiving the active drug. Statistical comparison between the two groups confirmed the greater efficacy and rapid action of the serrapeptase against all the symptoms examined at both stages. Tolerance was found to be very good and similar for both groups. It is concluded that serrapeptase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation. Serratiopeptidase is anti-inflammatory.
Serrapeptase and nattokinase
Q. There is a product out called that combines both nattokinase and serrapeptase enzymes. Is it advisable to take such a combination enzyme product?
A. Few human studies are available with either nattokinase or serrapeptase and hence it is very difficult to know what kind of effect the combination formula would have. To be on the safe side, it is advisable to learn how serrapeptase alone and nattokinase alone work for you before considering the combination.
Serrapeptase emails and questions
Q. Can serrapeptase cause adverse reactions when taking meds for high blood pressure such as Norvasc and Avapro? Because my mom takes those and they really afflict her badly. And what is the ideal serrapeptase dosage for me to take serrapeptase for chronic sinusitis. I've had that all my life. I need relief and not drugs.
A. We personally do not have enough experience with this nutrient to have an answer to these questions. Serrapeptase has been used in Japan but very little in the US so we really don't know much about the ideal dosage or what conditions it is likely to benefit, or how serrapeptase interacts with medicines.
Q. My father has found benefit using serrapeptase for his
leg claudication. He can now walk twice as far, but still not much, about 400m, but
he is 81! There is mention of serrapeptase breaking down plaque. If the effect of that is to clear
the arteries, wouldn't you expect it to reduce blood pressure?
A. This is a good questions but I prefer to wait for a serrapeptase studies are done regarding its influence on blood pressure before going out on a limb and making a statement that may turn out not to be accurate.
Q. I tried serrapeptase swallowed as a pill and did not
notice much effect on me. Then I tried it under the tongue, and so far I have
very good results. I have noticed a sharp decline in my post-op inflammation. It
is impossible to tell if this is a direct result of serapeptase or the result of
being almost six weeks recovered from back surgery. Please note that using this
serrapeptase product of yours under the tongue is like chewing sandpaper. If it
proves to be beneficial you may want to
reformulate it in such a way to be gentler to tender tissue.
A. This is an interesting way to use serrapeptase. We have no idea if it works better under the tongue or how safe it is to take serrapeptase this way.
Q. I just received my order of serrapeptase and was
wondering if serrapeptase is something you take every day, or for a certain
amount of time and take some time off and then take again. i am just concerned
about toxic effects from serrapeptase taking everyday?
A. Since little human research with serrapeptase is available in the West, it is preferable to take breaks from use until we learn more about the full clinical effects and side effect profile of serrapeptase. At this time we don't have full knowledge of potential serrapeptase allergic reactions, side effects, cautions or dangers, and how it interacts with medicines and other supplements. We also don't have a full understanding of which medical conditions serrapeptase is most effective for. Therefore, limit your use of serrapeptase to maximum 5 tablets per week.
Q. I saw on your web site that there is at least one other
person who has had a negative experience with this enzyme. I too was
disappointed and shocked as it caused me extreme muscle and joint pain after two
weeks. And it sounded like a product that could have really helped me. I took 2
caps serrapeptase (40,000 units each) on an empty stomach one hour before
breakfast. I did this for about three weeks. After I stopped the serrapeptase I
did notice some improvement, but it has been a week since then, and I'm still in
a lot of pain, joints and muscles.
A. We find this strange since this potential serrapeptase side effect has not been mentioned in the medical literature, yet you are the second person who has reported it to us in the past 3 years. We will keep monitoring this potential serrapeptase side effect. Perhaps the dosage was too high.
Q. I thought I'd let you know my experiences with serrapeptase (Serralone 400mg per capsule). I started using it in the hope that it would help reduce the appearance of my varicose veins (I am only 32). As it is also an anti-inflammatory I thought it may also help with my adult acne as my infections are prone to being very swollen and red. Well, it seems to have certainly helped with the acne swelling, my spots are not as inflamed and angry looking but I have developed an awful lot of spider/thread veins that I never had before and I didn't notice and difference to my varicose veins. I have stopped taking it now as I am worried about the thread vein situation worsening.
Q. I have looked through the previous newsletter articles
but can find nothing on serrepeptase. Are you able to advise serrapeptase dosage
and length of time that you consider safe to take the supplement (I have been
taking it for chronic sinus infection as well as osteoarthritis and ankylosing
spondilytis) and what sort of breaks you consider best.
A. The reason we do not have specific dosages and length of use is because there are hardly any human studies that can give us these answers. Hence, until we know more, we feel it is best to take frequent breaks and discuss with your doctor on further details. Your doctor may wish to read this page on serrapeptase.
Q. I refer to a category of systemic enzymes which are
fibrolytic — fibrolytic enzymes break down fibrin and reduce or prevent
scarring. Examples of these are serrapeptase and nattokinase. So, more
precisely, could a fibrolytic enzyme like serrapeptase possibly reduce the
fibrosis in an inflammation damaged esophagus (as in eosinophilic esophagitis)
or an inflammation-damaged airway, as seen in asthma? Both undergo eosinophilic
inflammation and with time, remodeling which includes fibrosis.
A. We really do not know, there is so little research done with serrapeptase, hopefully we will know more in the next few years.
Q. Are there any studies saying whether or not
serrapeptase would be helpful in costochondritis? Also, why would spider veins
be a symptom of serrapeptase use?
A. I am not sure why spider veins are related to the use of serrapeptase. I have not seen research regarding serrapeptase and costochondritis.
Q. I have read a lot about serrapeptase from your website
and I am wondering how it will help with scar tissues formed after myomectomy
surgery of six years ago. I read in your website that only little research
has been done on serrapeptase and edema which I interpret to mean scar tissues;
is this correct.
A. Edema is fluid accumulation in tissues, it is not a scar. We don't have any research on serrapeptase and post myomectomy scar formation.
Q. How is serrapeptase manufactured? Do they kill
silkworms to do it? I have several friends who are interested in a serrapeptase
product but they are all vegetarians.
A. Serrapeptase is made by specific bacteria found in the gut of silkworms and these bacteria "digest" their cocoons. That is the extent of our knowledge, the exact steps are not revealed to us by the manufacturer.
Q. I'm adding to your data re joint/muscle pain side effects - I ordered the enzyme from Nutri-Health - object was relief of sciatic pain from traumatic injury of several years ago, on the theory that the nerve might be irritated by scar tissue. Total relief after 48 hours (4 doses of 20,000), but I continued it for a few more days to see if it would help with knee pain from torn meniscus. Overall achiness and finally real pain kept increasing to the point that I was finding it difficult to move when I found your site with the few references that matched my experience. I recovered from that effect after 2 days and stayed off the enzyme for a couple of weeks. Last week I tried it again to be certain and within 2 days began the pain once again. This time I have stopped the serrapeptase for good. There is probably no interaction involved as I take no prescription drugs, but do take many antioxidants and other supplements that reduce inflammation. However, I do test positive for rheumatoid arthritis although I am symptom-free through a strict diet.
Q. I have a question about serratiopeptidase . Does it
have any possible benefits for people with multiple sclerosis condition , or it
would be not be advised to use it. I understand and know it may have some side
effects at any condition, but specific about autoimmune problems it have no
information at all. And people with multiple sclerosis in general will have
other problems with inflammation, pain, digestive problems and so on, so
theoretically serratiopeptidase looks like could be good support for that
A. A search on Medline using the keywords serrapeptase multiple sclerosis or using the keyword serratiopeptidase did not reveal any published studies.
Q. Am currently take another serrapeptase brand it is 10
mg , the pills you carry are 20,000 units. How does your
dosage compare taking two pills per day of the product I have?
A. The serrapeptase product formulated by Dr. Ray Sahelian, M.D. is 200 mg. This product is made by a FDA approved and inspected facility and can be fully be relied on to be accurate. We have no idea of the quality of serrapeptase sold by other companies and how they measure their dosage or the accuracy of their dosage.
Different misspellings that have been seen for serrapeptase include serapeptase and sierrapeptase
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Vitalzym with serrapeptase supplement information
Quantitation of serrapeptase in formulations by UV method
in the microplate format.
Curr Drug Deliv. 2008 Oct; ICMR, Dept of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560027, India.
Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. Serrapeptase enzyme was estimated in formulations by using microplate readers which uses the principle of vertical photometry. Further this method was validated and the robustness of this method was checked by estimating the drug in various formulations including liposomes and marketed tablet formulations. The proposed microplate UV-method for determination of serrapeptase in formulations is novel, simple, inexpensive, fast, specific and robust. Thus this method could be a better alternative for regular estimation of drug in the various marketed formulations of serrapeptase.
This serrapeptase page was last updated in 2009