Seselin research and benefit

Seselin in a coumarin derivative found in wild lettuce and other herbs. Seselin is an angular pyranocoumarin possesses both anti-inflammatory and antinociceptive properties.

Seselin from Plumbago zeylanica inhibits phytohemagglutinin (PHA)-stimulated cell proliferation in human peripheral blood mononuclear cells.
J Ethnopharmacol. 2008 Sep 2; National Research Institute of Chinese Medicine, No. 155-1, Sec. 2, Li-Nung Street, Shih-Pai, 112, Taipei, Taiwan.
Effects of seselin identified from Plumbago zeylanica on phytohemagglutinin (PHA)-stimulated cell proliferation were studied in human peripheral blood mononuclear cells (PBMC). The data demonstrated that seselin inhibited PBMC proliferation-activated with PHA. The action mechanisms of seselin may involve the regulation of cell cycle progression, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in PBMC. Since cell cycle analysis indicated that seselin arrested the cell cycle progression of activated PBMC from the G(1) transition to the S phase. Seselin suppressed IL-2 and IFN-gamma production in a concentration-dependent manner. Furthermore, seselin significantly decreased the IL-2 and IFN-gamma gene expression in PHA-activated PBMC. Therefore, results elucidated for the first time that seselin is likely an immune influencing agent for PBMC.

Biological activity of some coumarins from Sri Lankan Rutaceae.
J Nat Prod. 1994 Apr; Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin and xanthyletin were found to be active. Seselin also exhibited moderate cytotoxicity.

Seselin is found in
Apium graveolens
Plumbago zeylanica
Rutaceae

Synthesis and antinociceptive activity of seselin derivatives
Yao Xue Xue Bao. 2008 Sep; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Natural product seselin and related derivatives with an angular pyranocoumarin skeleton were synthesized from 8-acetyl-7-hydroxycoumarins by condensation with acetone, reduction, and dehydration successively under mild conditions with total yield of > 50%. Twelve seselin derivatives were tested by the writhing response assay induced by acetic acid at a dose of 40 mg x kg(-1). Seselin (4a) and 4,8,8-trimethyl-9,9-dihydro-pyran[2,3-f] chromene-2,10-dione (2b) showed obviously antinociceptive activity with inhibitory effect of 85% and 50%, respectively, more or quite potent than aspirin in the same assay, suggesting that seselin derivatives could be a novel kind of potential antinociceptive agents.

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